Abstract
This study defines the clinical characteristics and evolution of 16 epileptic children with hippocampal asymmetry (HA) without sclerosis on MRI. The association of a positive family history of epilepsy (11/16), low incidence of febrile seizures (2/16), and benign prognosis (seizure control in monotherapy in 11/16, mean follow-up = 4.3 years, range 1 to 10) suggest a different clinical presentation than patients with mesial temporal sclerosis. Genetic studies of these mostly French Canadian families should help confirm the existence of a distinct syndrome.
MeSH terms
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Adolescent
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Age Factors
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Age of Onset
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Anticonvulsants / therapeutic use
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Atrophy / complications*
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Atrophy / pathology*
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Atrophy / physiopathology
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Child
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Disease Progression
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Drug Resistance / genetics
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Epilepsy / diagnostic imaging
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Epilepsy / pathology*
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Epilepsy / physiopathology
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Family Health
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Female
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Functional Laterality / physiology*
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Hippocampus / diagnostic imaging
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Hippocampus / pathology*
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Hippocampus / physiopathology
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Humans
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Magnetic Resonance Imaging
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Male
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Predictive Value of Tests
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Prognosis
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Seizures, Febrile / epidemiology
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Tomography, X-Ray Computed