Epithelioid sarcoma. Flow cytometric study of DNA content and regional DNA heterogeneity

Cancer. 1992 Apr 1;69(7):1721-8. doi: 10.1002/1097-0142(19920401)69:7<1721::aid-cncr2820690713>3.0.co;2-3.

Abstract

The DNA content and regional DNA heterogeneity in correlation with clinicopathologic parameters and patient survival were investigated in epithelioid sarcoma. Such neoplasms preponderantly manifest diploid DNA content and a remarkably stable intratumoral and intertumoral DNA content. Small tumor size (less than 5.0 cm) and low S-phase fraction (less than 5%) were significant prognostic factors in this study. Ploidy status, mitotic rate, age, and postsurgical treatment were not significantly correlated with survival.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • DNA, Neoplasm / analysis*
  • DNA, Neoplasm / genetics
  • Female
  • Flow Cytometry
  • Follow-Up Studies
  • Genetic Variation / physiology
  • Humans
  • Male
  • Middle Aged
  • Ploidies
  • Sarcoma / chemistry*
  • Sarcoma / genetics
  • Sarcoma / mortality
  • Soft Tissue Neoplasms / chemistry*
  • Soft Tissue Neoplasms / genetics
  • Soft Tissue Neoplasms / mortality

Substances

  • DNA, Neoplasm