Abstract
Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Crystallography, X-Ray
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Guanosine Triphosphate / chemistry
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Humans
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Models, Biological
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Protein Biosynthesis
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Protein Conformation
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Protein Structure, Tertiary
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Protein Transport
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Ribosomes / metabolism
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Ribosomes / physiology*
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Saccharomyces cerevisiae Proteins / physiology
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Signal Recognition Particle* / physiology
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Signal Transduction
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Sulfolobus / physiology
Substances
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SRP54 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Signal Recognition Particle
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Guanosine Triphosphate