Decreases in glucocorticoid sensitivity as a factor of stress-producing changes in the activity of monoamine oxidase, lipid peroxidation, and behavior in rats

Neurosci Behav Physiol. 2004 Sep;34(7):697-701. doi: 10.1023/b:neab.0000036010.90414.d9.

Abstract

Four episodes of immobilization stress induced a decrease in the sensitivity of rats to glucocorticoid hormones, which was accompanied by anxiogenic behavior, increased MAO-B activity, and a parallel increase in lipid peroxidation (LPO) in brain tissues. There was a simultaneous increase in MAO-B activity in the kidneys and accumulation of LPO products in the liver and kidneys. Administration of Kenalog (2 mg/kg), a pharmacological analog of glucocorticoid hormones, prevented the poststress activation of MAO-B and LPO and decreased the extent of anxiogenic behavioral abnormalities in rats.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology
  • Brain / drug effects
  • Brain / enzymology
  • Female
  • Glucocorticoids / pharmacology*
  • Kidney / drug effects
  • Kidney / enzymology
  • Lipid Peroxidation / drug effects*
  • Lipid Peroxidation / physiology
  • Liver / drug effects
  • Liver / enzymology
  • Locomotion / drug effects
  • Locomotion / physiology
  • Male
  • Monoamine Oxidase / metabolism*
  • Motor Activity / drug effects
  • Rats
  • Restraint, Physical / methods
  • Statistics, Nonparametric
  • Stress, Physiological* / enzymology
  • Stress, Physiological* / physiopathology
  • Triamcinolone Acetonide / pharmacology

Substances

  • Glucocorticoids
  • Monoamine Oxidase
  • Triamcinolone Acetonide