Abstract
The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / genetics*
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Antigens, Bacterial / immunology
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Bordetella pertussis / classification
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Bordetella pertussis / genetics
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Bordetella pertussis / isolation & purification*
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Bordetella pertussis / metabolism
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Canada
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Fimbriae Proteins / chemistry
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Fimbriae Proteins / genetics*
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Fimbriae Proteins / immunology
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Humans
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Molecular Sequence Data
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Mutation
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Pertussis Vaccine
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Polymorphism, Genetic*
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Sequence Analysis, DNA
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Serotyping
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Virulence Factors, Bordetella / chemistry
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Virulence Factors, Bordetella / genetics*
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Virulence Factors, Bordetella / immunology
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Whooping Cough / microbiology
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Whooping Cough / prevention & control
Substances
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Antigens, Bacterial
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Pertussis Vaccine
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Virulence Factors, Bordetella
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fim3 protein, Bordetella
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Fimbriae Proteins
Associated data
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GENBANK/AY464179
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GENBANK/AY464180
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GENBANK/AY464181