Abstract
Respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract illness in infants and the elderly. Presently, no safe and efficacious RSV vaccine exists; however, advances in our understanding of immunity and the pathogenesis of disease associated with RSV infection may lead to new vaccine strategies. RSV G protein contains a CX3C chemokine motif that interacts with the CX3CR1 chemokine receptor and modifies the activities of fractalkine. In the present study, we show that anti-RSV G protein antibody responses after recent RSV infection or vaccination are associated with inhibition of RSV G protein CX3C-CX3CR1 interaction and RSV G protein-mediated leukocyte chemotaxis.
Publication types
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Clinical Trial
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antibodies, Viral / analysis
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Antibodies, Viral / biosynthesis*
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Binding Sites, Antibody
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CX3C Chemokine Receptor 1
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Chemokine CX3CL1
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Chemokines, CX3C / chemistry
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Chemokines, CX3C / immunology*
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Chemotaxis, Leukocyte
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Child, Preschool
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Humans
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Infant
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Leukocytes / immunology
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Membrane Proteins / immunology*
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Receptors, Chemokine / immunology*
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Respiratory Syncytial Virus Infections / immunology*
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Respiratory Syncytial Virus Infections / prevention & control
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Respiratory Syncytial Virus Infections / virology
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Respiratory Syncytial Virus Vaccines / administration & dosage
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Respiratory Syncytial Virus Vaccines / immunology*
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Respiratory Syncytial Virus, Human / immunology*
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Vaccination
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / immunology
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Viral Proteins / antagonists & inhibitors
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Viral Proteins / chemistry
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Viral Proteins / immunology*
Substances
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Antibodies, Viral
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CX3C Chemokine Receptor 1
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CX3CL1 protein, human
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CX3CR1 protein, human
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Chemokine CX3CL1
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Chemokines, CX3C
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Membrane Proteins
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Receptors, Chemokine
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Respiratory Syncytial Virus Vaccines
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Vaccines, Attenuated
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Viral Proteins