Enantioselective formal hydration of alpha,beta-unsaturated imides by Al-catalyzed conjugate addition of oxime nucleophiles

J Am Chem Soc. 2004 Nov 17;126(45):14724-5. doi: 10.1021/ja045563f.

Abstract

The (salen)Al-catalyzed asymmetric conjugate addition of salicylaldoxime to alpha,beta-unsaturated imides is the key step in an efficient and highly enantioselective two-step formal hydration of these electron-deficient olefins. This reaction constitutes the first example of an enantioselective conjugate addition of an oxygen-centered nucleophile to alpha,beta-unsaturated carboxylic acid derivatives. Application of this method to chiral, nonracemic substrates revealed a high level of catalyst-induced diastereoselectivity, underscoring its potential utility for polyketide natural product synthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohols / chemical synthesis
  • Alkanes / chemistry
  • Aluminum / chemistry*
  • Carboxylic Acids / chemical synthesis*
  • Catalysis
  • Imides / chemistry*
  • Oximes / chemistry*
  • Stereoisomerism

Substances

  • Alcohols
  • Alkanes
  • Carboxylic Acids
  • Imides
  • Oximes
  • Aluminum