Magnetic nanoparticle assemblies on denatured DNA show unusual magnetic relaxivity and potential applications for MRI

Chem Commun (Camb). 2004 Nov 21:(22):2560-1. doi: 10.1039/b409603g. Epub 2004 Sep 27.

Abstract

Denatured (substantially single-stranded) herring sperm DNA acts as a template for the preparation of magnetic nanowires, forming stable aqueous suspensions, which exhibit unprecedentedly high relaxivity at low field, suggesting that the material may be a potentially useful reagent for MRI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media
  • DNA / chemistry*
  • Fishes
  • Magnetic Resonance Imaging
  • Magnetics*
  • Male
  • Nanotechnology*
  • Nucleic Acid Denaturation*
  • Spermatozoa / chemistry

Substances

  • Contrast Media
  • DNA