Abstract
To assess prevalence of nelfinavir resistance mutations in children receiving highly active antiretroviral therapy, sequencing of protease gene from plasma of 53 human immunodeficiency virus-infected children was performed. The prevalence of L90M was similar to that of D30N. There was a significant correlation with a higher viral load and lower age and the occurrence of L90M. These findings suggest differential molecular age- and viral load-related routes for nelfinavir resistance.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Antiretroviral Therapy, Highly Active / methods*
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Child
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Child, Preschool
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Cohort Studies
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Drug Resistance, Viral / genetics*
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Female
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HIV Infections / diagnosis
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HIV Infections / drug therapy*
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HIV-1 / drug effects*
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HIV-1 / genetics
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HIV-1 / isolation & purification
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Humans
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Male
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Microbial Sensitivity Tests
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Mutation
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Nelfinavir / pharmacology
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Nelfinavir / therapeutic use*
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Pharmacogenetics
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Risk Factors
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Sampling Studies
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Sensitivity and Specificity
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Viral Load