Abstract
A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / classification
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Antioxidants / pharmacology
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Aorta / drug effects
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Aorta / physiology
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Arteriosclerosis / prevention & control*
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Ascorbic Acid / antagonists & inhibitors
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Ascorbic Acid / pharmacology
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Ferrous Compounds / antagonists & inhibitors
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Ferrous Compounds / pharmacology
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Hepatocytes / drug effects
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Hepatocytes / metabolism
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Hypolipidemic Agents / chemical synthesis*
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Hypolipidemic Agents / classification
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Hypolipidemic Agents / pharmacology
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Lipid Peroxidation / drug effects
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Male
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Membrane Lipids / metabolism
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Nitric Oxide Donors / chemical synthesis*
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Nitric Oxide Donors / classification
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Nitric Oxide Donors / pharmacology
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Phenols / chemical synthesis
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Phenols / chemistry
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Phenols / pharmacology
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Phenylephrine / antagonists & inhibitors
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Phenylephrine / pharmacology
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Rats
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Rats, Wistar
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Structure-Activity Relationship
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Thiobarbituric Acid Reactive Substances / analysis
Substances
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Antioxidants
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Ferrous Compounds
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Hypolipidemic Agents
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Membrane Lipids
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Nitric Oxide Donors
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Phenols
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Thiobarbituric Acid Reactive Substances
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Phenylephrine
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Ascorbic Acid