Multidrug resistance reversal activity of permethyl ningalin B amide derivatives

Houchao Tao; Inkyu Hwang; Dale L Boger

doi:10.1016/j.bmcl.2004.10.002

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives

Bioorg Med Chem Lett. 2004 Dec 20;14(24):5979-81. doi: 10.1016/j.bmcl.2004.10.002.

Authors

Houchao Tao¹, Inkyu Hwang, Dale L Boger

Affiliation

¹ Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

PMID: 15546712
DOI: 10.1016/j.bmcl.2004.10.002

Abstract

A series of amide derivatives of permethyl ningalin B were prepared and examined as multidrug resistance (MDR) reversal agents illustrating that the C5 carboxylate is widely tolerant of such derivatization.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects
ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
Amides / chemical synthesis
Amides / chemistry*
Amides / pharmacology
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Survival / drug effects
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Heterocyclic Compounds, 3-Ring / chemical synthesis
Heterocyclic Compounds, 3-Ring / chemistry
Heterocyclic Compounds, 3-Ring / pharmacology*
Humans
Molecular Structure
Structure-Activity Relationship

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Amides
Antineoplastic Agents
Heterocyclic Compounds, 3-Ring
ningalin B

Grants and funding

CA42056/CA/NCI NIH HHS/United States