A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population

H Thude; S Rosenhahn; W Hunger-Dathe; U-A Müller; D Barz

doi:10.1111/j.1365-2370.2004.00479.x

A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population

Eur J Immunogenet. 2004 Dec;31(6):245-7. doi: 10.1111/j.1365-2370.2004.00479.x.

Authors

H Thude¹, S Rosenhahn, W Hunger-Dathe, U-A Müller, D Barz

Affiliation

¹ Institute for Transfusion Medicine, University of Jena, Jena, Germany. [email protected]

PMID: 15548260
DOI: 10.1111/j.1365-2370.2004.00479.x

Abstract

To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D.

MeSH terms

Diabetes Mellitus, Type 1 / genetics*
Diabetes Mellitus, Type 1 / immunology
Exons
Genetic Predisposition to Disease*
Genotype
Germany
Humans
Leukocyte Common Antigens / genetics*
Leukocyte Common Antigens / immunology
Point Mutation*
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Sequence Analysis, DNA

Substances

Leukocyte Common Antigens
Protein Tyrosine Phosphatase, Non-Receptor Type 1