Abstract
An antifungal glycolipid was purified from the culture liquid of the ustilaginomycetous yeast Sympodiomycopsis paphiopedili by column and thin-layer chromatography. According to nuclear magnetic resonance and mass-spectroscopy experiments it was a cellobioside containing 2,15,16-trihydroxypalmitic acid as an aglycon. The minimal effective concentrations leading to ATP leakage and growth inhibition were 45 and 160 microg ml(-1) for Cryptococcus terreus and Candida albicans, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Basidiomycota / chemistry
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Basidiomycota / metabolism*
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Basidiomycota / physiology
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Candida albicans / growth & development
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Chromatography, Thin Layer
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Cryptococcus / growth & development
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Glycolipids / chemistry*
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Glycolipids / isolation & purification
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Glycolipids / metabolism
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Glycolipids / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antifungal Agents
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Glycolipids
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Adenosine Triphosphate