Abstract
Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Bacterial Outer Membrane Proteins / immunology*
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Entamoeba histolytica / immunology*
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Gerbillinae
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Humans
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Lectins / immunology*
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Liver Abscess, Amebic / prevention & control*
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Recombinant Fusion Proteins / immunology*
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Vaccination
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Vaccines, Synthetic / immunology*
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Yersinia enterocolitica / genetics*
Substances
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Bacterial Outer Membrane Proteins
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Lectins
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Recombinant Fusion Proteins
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Vaccines, Synthetic
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yopE protein, Yersinia