Abstract
This review consolidates biological activity data reported for pyridoacridine 1 molecules in the literature from 1983-2003 into several tables with brief discussions of assays used and results obtained. This review summarizes recent progress in structure activity relationships for analogues of amphimedine 2 and ascididemin 3 classes of pyridoacridines and correlates reported molecular mechanisms of action with biological activities.
MeSH terms
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Acridines / chemistry
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Acridines / pharmacology*
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Alkaloids / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antiparasitic Agents / chemistry
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Antiparasitic Agents / pharmacology*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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DNA / metabolism
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Phenanthrolines / chemistry
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Phenanthrolines / pharmacology*
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Quinolines / pharmacology
Substances
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Acridines
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Alkaloids
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Antifungal Agents
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Antineoplastic Agents
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Antiparasitic Agents
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Antiviral Agents
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Phenanthrolines
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Quinolines
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pyridoacridine
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ascididemin
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amphimedine
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DNA