Abstract
One of the most used and useful polymers, poly(ethylene glycol) (PEG) was used as a carrier for warfarin. The drug-polymer conjugate was freely water soluble at room temperature. The hydrolytic stability of the PEG-warfarin was investigated at physiological pH and confirmed the stability of the conjugate. In vivo release studies demonstrated a good release of parent drug, without the initial high plasma level of warfarin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Calibration
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Electrochemistry
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Injections, Intraperitoneal
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Intubation, Gastrointestinal
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Male
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Polyethylene Glycols / administration & dosage
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacokinetics*
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Rabbits
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Warfarin / administration & dosage
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Warfarin / blood
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Warfarin / chemistry
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Warfarin / pharmacokinetics*
Substances
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Polyethylene Glycols
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Warfarin