The paper presents the results of examination using a standardized multifactorial personality study schedule in patients with pulmonary tuberculosis, residents in the Samara Region, including 123 males and 55 females with first diagnosed tuberculosis, 152 males and 101 females with chronic pulmonary tuberculosis. Ninety-eight apparently healthy males and 142 females of the same age were examined as a control group. The type of a response in the psychotraumatic situation and psychological traits were identified. The leading type of a response (66%) was hyposthenic (an inhibitory response to stress) in males with first identified tuberculosis. Conflict somatization was peculiar to other males, as in 46% of the females. The behavioral type of dysadaptation and asocial and antisocial responses occur in 38.9% of the males with chronic pulmonary tuberculosis and in 25% of the females. 22.2% of the males and 50% of the females show a somatic response, which leads to the transition to the psychophysiological level, to the occurrence of psychosomatic diseases. Irrespective of the duration of the disease, all the patients, both males and females, need psychological correction.