Abstract
We report the prevalence of human papillomavirus (HPV) types in 100 cervical biopsy specimens in Mazandaran province. HPV DNA was detected in 78.6% of cervical carcinoma cases, 64.3% of dys/ metaplasia and 9% of normal cases. Significant correlation was found between the presence of HPV DNA and development of cervical carcinoma. HPV types 16 and 18 were detected in 60.6% of HPV-positive cervical carcinoma cases, whereas HPV31 and 33 were found in 21.2%, and HPV6 and 11 in 18.2%. Among HPV-positive dys/metaplasia cases, 55.6% were positive for HPV16 and 18, 22.3% for HPV6 and 11, and 11.1% for HPV31 and 33. Only HPV6 and 11 were detected in 4 (100%) normal biopsy specimens.
MeSH terms
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Biopsy
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Case-Control Studies
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Cocarcinogenesis
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DNA, Viral / analysis
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DNA, Viral / genetics
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Female
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Genotype
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Humans
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In Situ Hybridization / methods
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Iran / epidemiology
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Molecular Epidemiology
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Papillomaviridae / classification
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Papillomaviridae / genetics*
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Papillomavirus Infections / epidemiology*
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Papillomavirus Infections / pathology
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Papillomavirus Infections / virology*
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Polymerase Chain Reaction / methods
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Population Surveillance
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Prevalence
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Time Factors
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Uterine Cervical Dysplasia / epidemiology*
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Uterine Cervical Dysplasia / pathology
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Uterine Cervical Dysplasia / virology*
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Uterine Cervical Neoplasms / epidemiology*
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Uterine Cervical Neoplasms / pathology
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Uterine Cervical Neoplasms / virology*