Abstract
Two series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and antimicrobial agents. The compounds that could be conveniently prepared in a few steps processes from natural safrole have been characterised by IR and 1H-NMR spectroscopy. In vivo antitumor activity tests showed that some of the compounds were able to inhibit carcinoma S-180 tumour growth in mice. The in vitro antimicrobial activity of all compounds revealed that they are able to promote the growth of some organisms, including Bacillus subtilis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Bacillus subtilis / drug effects
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Bacillus subtilis / growth & development
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Behavior, Animal / drug effects
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Dioxoles / chemical synthesis*
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Dioxoles / pharmacology
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Dioxoles / toxicity
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Drug Evaluation, Preclinical
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Lethal Dose 50
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Mice
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Peptides / chemical synthesis*
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Peptides / pharmacology
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Phenylalanine / analogs & derivatives*
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Phenylalanine / chemical synthesis
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Phenylalanine / pharmacology
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Phenylalanine / toxicity
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Safrole / chemistry
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Sarcoma 180 / drug therapy
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Dioxoles
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N-(6-allyl-1,3-benzodioxol-5-yl)-N-(tert-butoxycarbonyl)phenylalaninamide
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Peptides
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Phenylalanine
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Safrole