Splitting the dynamics of large biochemical interaction networks

J Theor Biol. 2005 Feb 7;232(3):375-84. doi: 10.1016/j.jtbi.2004.08.018.

Abstract

This article is inscribed in the general motivation of understanding the dynamics on biochemical networks including metabolic and genetic interactions. Our approach is continuous modeling by differential equations. We address the problem of the huge size of those systems. We present a mathematical tool for reducing the size of the model, master-slave synchronization, and fit it to the biochemical context.

MeSH terms

  • Algorithms
  • Animals
  • Cell Physiological Phenomena
  • Gene Expression Regulation
  • Models, Biological*
  • Systems Biology / methods*