Abstract
Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the liver and the kidney, while Nic-BZA demonstrated stability against enzymes present in these organs and fluids.
MeSH terms
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Animals
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Anticonvulsants / isolation & purification
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Anticonvulsants / pharmacokinetics*
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Anticonvulsants / pharmacology
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Benzyl Compounds / isolation & purification
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Benzyl Compounds / pharmacokinetics*
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Benzyl Compounds / pharmacology
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Body Fluids / chemistry
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Body Fluids / metabolism*
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Brain Chemistry
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Chromatography, High Pressure Liquid
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Drug Stability
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Kidney / chemistry
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Kidney / metabolism
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Liver / chemistry
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Liver / metabolism
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Lung / metabolism
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Niacin / analogs & derivatives*
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Niacin / isolation & purification
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Niacin / pharmacokinetics*
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Niacin / pharmacology
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Picolinic Acids / isolation & purification
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Picolinic Acids / pharmacokinetics*
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Picolinic Acids / pharmacology
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Rats
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Time Factors
Substances
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Anticonvulsants
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Benzyl Compounds
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Picolinic Acids
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nicotinic acid benzylamide
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picolinic acid benzylamide
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Niacin