Abstract
Two new lactones (1, 2), descurainolide A and B, and one new aryl-8-oxa-bicyclo[3,2,1]-oct-3-en-2-one (3), descurainin, together with five known compounds (4-8), were isolated from the seeds of Descurainia sophia (L.) WEBB ex PRANTL. The structures of the new compounds were elucidated by extensive studies of their 1D, 2D NMR and HR-MS. Compounds 4 and 5 showed cytotoxicity.
MeSH terms
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Alkenes / chemistry*
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Alkenes / isolation & purification
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Alkenes / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Brassicaceae / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Lactones / chemistry*
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Lactones / isolation & purification
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Tetrazolium Salts
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Thiazoles
Substances
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Alkenes
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Antineoplastic Agents, Phytogenic
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Bridged Bicyclo Compounds, Heterocyclic
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Lactones
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Tetrazolium Salts
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Thiazoles
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descurainolide A
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descurainolide B
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thiazolyl blue