The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha

Adv Enzyme Regul. 2004:44:75-92. doi: 10.1016/j.advenzreg.2003.11.017.

Authors

Carsten Willam¹, Lynn G Nicholls, Peter J Ratcliffe, Christopher W Pugh, Patrick H Maxwell

Affiliation

¹ Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

PMID: 15581484
DOI: 10.1016/j.advenzreg.2003.11.017

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA-Binding Proteins / physiology*
Dioxygenases
Humans
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-Inducible Factor-Proline Dioxygenases
Neoplasms / pathology
Neoplasms / physiopathology
Nuclear Proteins / physiology*
Oxygen / metabolism
Procollagen-Proline Dioxygenase / metabolism*
Transcription Factors / physiology*

Substances

DNA-Binding Proteins
HIF1A protein, human
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Nuclear Proteins
Transcription Factors
Dioxygenases
Procollagen-Proline Dioxygenase
EGLN3 protein, human
Hypoxia-Inducible Factor-Proline Dioxygenases
Oxygen