Abstract
Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in the 5' long terminal repeat (LTR) were examined among 28 drug-naive individuals. Twenty-four subjects had highly conserved LTR sequences, however, more significant changes were observed in the remaining four LTR sequences. These included a 9-bp deletion preceding the NF kappa B elements and a duplication of the RBF-2 motif. A higher overall frequency of mutations within the LTR occurred within NFAT-1 and Sp-1 sequences. Importantly, a novel 16-bp deletion was found in the distal NFAT-1 site.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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HIV Infections / drug therapy*
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HIV Infections / virology
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HIV Long Terminal Repeat / genetics*
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HIV-1 / genetics*
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Humans
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Molecular Sequence Data
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Mutation*
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Proviruses / genetics*
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Sequence Analysis, DNA
Associated data
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GENBANK/AY353928
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GENBANK/AY353929
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GENBANK/AY353930
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GENBANK/AY353931
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GENBANK/AY353932
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