This study examined barriers to vigorous physical activity (VPA) among 132 students transitioning from high school to the first year of a university. An ecological framework was used to classify barriers, and coping self-efficacy (CSE) and task self-efficacy (TSE) were investigated as predictors of VPA. Consistent with population data, 47% of the sample failed to meet national recommendations for VPA. Participants most often cited institutional, intrapersonal, and interpersonal barriers. CSE predicted TSE, which predicted VPA. A greater understanding of ecologically categorized barriers and the relationship of self-efficacy to VPA may aid health care practitioners in the design of targeted interventions to facilitate VPA and health among freshmen students.