Abstract
In guinea pig ventricular cardiomyocytes, the R(-)-enantiomer of efonidipine concentration-dependently blocked T-type Ca2+ current with 85% inhibition at 1 microM. In contrast, R(-)-efonidipine (1 microM) had no effect on the L-type Ca2+ current and Ca2+ transient in cardiomyocytes and contractile force in papillary muscles. Thus, R(-)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardia.
MeSH terms
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Animals
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Calcium Channel Blockers / pharmacology*
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Calcium Channels, L-Type / drug effects*
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Calcium Channels, T-Type / drug effects*
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Dihydropyridines / pharmacology*
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Guinea Pigs
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Heart / drug effects*
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Heart / physiology
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Heart Ventricles
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Nitrophenols / pharmacology*
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Organophosphorus Compounds / pharmacology*
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Stereoisomerism
Substances
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Calcium Channel Blockers
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Calcium Channels, L-Type
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Calcium Channels, T-Type
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Dihydropyridines
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Nitrophenols
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Organophosphorus Compounds
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efonidipine