An analysis of state of health among people living in Kiev over 1985-2000 was carried out. It is determined that birth rate decreases and mortality increases constantly. Life expectancy decreased too. Substantial and steady tendency of rising most of diseases is observed in the city. Diseases of cardiovascular system, thyroid gland, digestive system, urogenital system and different neoplasm are diagnosed nowadays more frequently than earlier. Children population presents with more increasing respiratory diseases, illnesses of organs of sense, nervous system, digestive system and blood as well as social diseases. Atmosphere is polluted with aromatic and saturated hydrocarbons, carbon oxide, nitric oxide, 3-4-benzpyrene, sulphurous anhydrides. The article presents data concerning negative tendency in demographic situation and the population's state of health in Kiev and air pollution. All above mentioned necessitate to develop well-founded adequate prophylactic measures to improve the situation.