Copper-catalyzed synthesis of vinyl sulfides

Org Lett. 2004 Dec 23;6(26):5005-8. doi: 10.1021/ol0477935.

Abstract

[reaction: see text] We report a method for the synthesis of vinyl sulfides using the soluble copper(I) catalyst [Cu(phen)(PPh3)2]NO3. The desired vinyl sulfides are obtained in good to excellent yields, with retention of stereochemistry. This protocol tolerates a wide variety of functional groups or substrates, is palladium-free, and does not require the use of expensive or air-sensitive additives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper / chemistry*
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Sulfhydryl Compounds / chemical synthesis*
  • Sulfhydryl Compounds / chemistry
  • Vinyl Compounds / chemical synthesis*
  • Vinyl Compounds / chemistry

Substances

  • Organometallic Compounds
  • Sulfhydryl Compounds
  • Vinyl Compounds
  • Copper