Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine

Cancer Res. 1979 Jul;39(7 Pt 1):2406-13.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Weight
  • Digestive System / drug effects*
  • Digestive System / metabolism
  • Dose-Response Relationship, Drug
  • Floxuridine / metabolism
  • Floxuridine / toxicity*
  • Fluorouracil / metabolism
  • Fluorouracil / toxicity*
  • Lethal Dose 50
  • Male
  • Mice
  • Mice, Inbred CBA
  • RNA / biosynthesis
  • Time Factors
  • Uridine / analogs & derivatives*
  • Uridine / metabolism

Substances

  • Floxuridine
  • RNA
  • Fluorouracil
  • Uridine