Transcription factors, pancreatic development, and beta-cell maintenance

M E Cerf; C J F Muller; D F Du Toit; J Louw; S A Wolfe-Coote

doi:10.1016/j.bbrc.2004.10.217

Transcription factors, pancreatic development, and beta-cell maintenance

Biochem Biophys Res Commun. 2005 Jan 28;326(4):699-702. doi: 10.1016/j.bbrc.2004.10.217.

Authors

M E Cerf¹, C J F Muller, D F Du Toit, J Louw, S A Wolfe-Coote

Affiliation

¹ Diabetes Research Group, Medical Research Council, Tygerberg, South Africa. [email protected]

PMID: 15607725
DOI: 10.1016/j.bbrc.2004.10.217

Abstract

Transcription factors play an important role during pancreatic development ensuring normal differentiation of the islet endocrine cells. In mature beta-cells, expression of specific transcription factors is essential in maintaining normal beta-cell function.

Publication types

Review

MeSH terms

Animals
Cell Differentiation
Diabetes Mellitus, Type 2 / metabolism*
Diabetes Mellitus, Type 2 / pathology
Gene Expression Regulation, Developmental
Humans
Islets of Langerhans / growth & development*
Islets of Langerhans / metabolism*
Islets of Langerhans / pathology
Pancreas / embryology
Pancreas / growth & development*
Pancreas / metabolism*
Pancreas / pathology
Transcription Factors / metabolism*

Substances

Transcription Factors