A new polymer-supported reagent for the synthesis of beta-lactams in solution

J Org Chem. 2004 Dec 24;69(26):9316-8. doi: 10.1021/jo048400i.

Abstract

A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of beta-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Indicators and Reagents / chemistry*
  • Polymers / chemistry*
  • Solutions
  • beta-Lactams / chemical synthesis*
  • beta-Lactams / chemistry

Substances

  • Indicators and Reagents
  • Polymers
  • Solutions
  • beta-Lactams