Abstract
In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology*
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Chemistry, Pharmaceutical / methods
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Hydrazines / chemical synthesis
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Hydrazines / pharmacology
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Microbial Sensitivity Tests / methods
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Molecular Structure
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Quantitative Structure-Activity Relationship
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Semicarbazides / chemical synthesis
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Semicarbazides / pharmacology
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Technology, Pharmaceutical / methods
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Thiones / chemical synthesis*
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Thiones / pharmacology*
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Thiophenes / chemical synthesis
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Thiophenes / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / pharmacology*
Substances
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Antifungal Agents
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Hydrazines
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Semicarbazides
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Thiones
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Thiophenes
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Triazoles
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1,2,4-triazole
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thiosemicarbazide