Abstract
Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Computational Biology / methods
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Forkhead Transcription Factors
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Gene Expression Regulation / genetics*
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Gene Expression Regulation / physiology
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Humans
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Nuclear Proteins / genetics*
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Nuclear Proteins / metabolism
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Response Elements / genetics*
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Sequence Analysis, DNA / methods*
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Signal Transduction / genetics*
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Signal Transduction / physiology
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Transcription Factors / genetics*
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Transcription Factors / metabolism
Substances
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Forkhead Transcription Factors
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Nuclear Proteins
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Transcription Factors