1 Department of Anesthesiology, Turku University Hospital, [email protected] (Laitio) Department of Theoretical Physics, Turku University, Turku, Finland (Kuusela) Division of Cardiology, Department of Medicine, Oulu University Hospital, Oulu, Finland (Huikuri) Department of Anesthesiology, Turku University Hospital (Jalonen, Kentala) Division of Cardiology, Department of Medicine, Oulu University Hospital, Oulu, Finland (Mäkikallio) Department of Biostatistics, University of Turku (Helenius) Departments of Physiology and Clinical Physiology, Turku University Hospital (Pullisaar, Hartiala) Turku PET Centre and the Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland (Scheinin).