Abstract
The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of Aspergillus niger. The gross structure of 1 was determined by 2D NMR studies and comparison with literature data, and the absolute stereochemistry was elucidated by chiral HPLC analysis of the hydrolysis products.
MeSH terms
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Aspergillus niger / chemistry*
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Australia
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Chromatography, High Pressure Liquid
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Chromones / chemistry
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Chromones / isolation & purification
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Diketopiperazines
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Piperazines / chemistry*
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Piperazines / isolation & purification
Substances
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Chromones
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Coumarins
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Diketopiperazines
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Piperazines
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TMC 256A1
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TMC 256C1
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demethylkotanin