Sesquiterpenes from the mycelial cultures of Dichomitus squalens

J Nat Prod. 2004 Dec;67(12):2121-3. doi: 10.1021/np0497144.

Abstract

Three new sesquiterpenes including a rearranged hirsutane, dichomitol (1), an aromadendrane, 2beta,13-dihydroxyledol (2), and a 1,10-seco-2,3-seco-aromadendrane, dichomitone (3), were isolated from mycelial solid cultures of Dichomitus squalens. Their structures were elucidated by spectroscopic methods, and their nematicidal activities against Bursaphelenchus xylophilus were assessed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antinematodal Agents / chemistry
  • Antinematodal Agents / isolation & purification*
  • Antinematodal Agents / pharmacology
  • Molecular Structure
  • Nematoda / drug effects*
  • Nuclear Magnetic Resonance, Biomolecular
  • Polyporaceae / chemistry*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • 2beta,13-dihydroxyledol
  • Antinematodal Agents
  • Sesquiterpenes
  • dichomitol
  • dichomitone