Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics

Qiu Bin; Wang Wei; Yuwu Chi; Guonan Chen

doi:10.1016/j.ab.2004.09.028

Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics

Anal Biochem. 2005 Jan 15;336(2):196-201. doi: 10.1016/j.ab.2004.09.028.

Authors

Qiu Bin¹, Wang Wei, Yuwu Chi, Guonan Chen

Affiliation

¹ Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China.

PMID: 15620884
DOI: 10.1016/j.ab.2004.09.028

Abstract

The electrochemical behaviors of diethylstilbestrol (DES) at a glassy carbon electrode were investigated by cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry (DPV). Based on these, a sensitive and selective DPV method was developed for determination of DES. The linear response range of DES is 1.0 x 10(-4)-2.0 x 10(-6) mol/L and the detection limit was 8.0 x 10(-8) mol/L. The developed method has been used for the pharmacokinetics of DES in rabbit blood plasma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diethylstilbestrol / chemistry*
Diethylstilbestrol / pharmacokinetics*
Electrochemistry
Hydrogen-Ion Concentration
Molecular Structure
Oxidation-Reduction
Rabbits
Surface-Active Agents / pharmacology

Substances

Surface-Active Agents
Diethylstilbestrol