Abstract
A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)(2)(PYNI)](2+) (bpy=2,2'-bipyridine, PYNI=2-(2'-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and (1)H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)(2)(PYNI)](2+) binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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DNA / drug effects*
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In Vitro Techniques
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Intercalating Agents / chemical synthesis
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Intercalating Agents / chemistry
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Intercalating Agents / pharmacology
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Ligands
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Luminescence
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
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Organometallic Compounds / pharmacology*
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Photochemistry
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Plasmids / drug effects
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Ruthenium
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry
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Thermodynamics
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Viscosity
Substances
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Intercalating Agents
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Ligands
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Organometallic Compounds
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Ruthenium
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DNA