Two new cases of familial hairy cell leukemia associated with HLA haplotypes A2, B7, Bw4, Bw6

Leuk Lymphoma. 2005 Feb;46(2):243-5. doi: 10.1080/10428190400013589.

Abstract

Hairy cell leukemia (HCL) is a rare hematological disorder of unknown origin. Thirteen familial cases of HCL have been reported, with 28 relatives affected. Here we report 2 cases of HCL in a family associated with HLA haplotypes A2, B7 and Bw4/6.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Family Health
  • Female
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics*
  • HLA-A2 Antigen
  • HLA-B Antigens
  • HLA-B7 Antigen
  • Haplotypes*
  • Humans
  • Leukemia, Hairy Cell / genetics
  • Leukemia, Hairy Cell / immunology*
  • Male
  • Middle Aged
  • Pedigree

Substances

  • HLA Antigens
  • HLA-A2 Antigen
  • HLA-B Antigens
  • HLA-B7 Antigen
  • HLA-Bw4 antigen
  • HLA-Bw6 antigen