Reactivation of varicella-zoster virus (VZV) usually leads to developing of characteristic skin lesions with dermatomal distribution. In very rare cases typical clinical picture can be absent, which impairs diagnostic procedure. Atypical case of young non HIV infected man was described. Clinical picture of meningitis and hepatitis due to VZV reactivation without typical skin eruptions resulted in diagnostic problems and required differentiation with proliterative process. Essential role of serologic testing in such cases was emphasized.