Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin

Biofactors. 2004;21(1-4):371-3. doi: 10.1002/biof.552210171.

Abstract

Dioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR). We have previously demonstrated that certain natural flavones and flavonols at the dietary levels suppress AhR transformation. In this study, we investigated whether 5 anthocyanidins, 15 anthocyanins, and protocatechuic acid suppress AhR transformation in mouse hepatoma Hepa-1c1c7 cells. All the compounds tested here at 5 microM unexpectedly failed to suppress the transformation induced by 0.1 nM TCDD, indicating that anthocyan does not have a potential to prevent dioxin toxicity.

MeSH terms

  • Animals
  • Anthocyanins / pharmacology*
  • Carcinoma, Hepatocellular
  • Cell Line, Tumor
  • Hydroxybenzoates / pharmacology
  • Liver Neoplasms
  • Mice
  • Plant Extracts / pharmacology*
  • Polychlorinated Dibenzodioxins / pharmacology*
  • Receptors, Aryl Hydrocarbon / biosynthesis*
  • Receptors, Aryl Hydrocarbon / drug effects

Substances

  • Anthocyanins
  • Hydroxybenzoates
  • Plant Extracts
  • Polychlorinated Dibenzodioxins
  • Receptors, Aryl Hydrocarbon
  • protocatechuic acid