The natural history of unruptured intracranial aneurysms

Neurosurg Focus. 2004 Nov 15;17(5):E3. doi: 10.3171/foc.2004.17.5.3.

Abstract

Since the publication of preliminary results from the International Study of Unruptured Intracranial Aneurysms in 1998 there has been a great deal of debate concerning the natural history of these lesions and their attendant risk of aneurysmal subarachnoid hemorrhage. Therefore, the authors reviewed a selected number of crucial studies concerning this topic to determine the best evidence-based estimate of a rupture rate for these lesions. Based on this analysis, the yearly risk of bleeding for an unruptured intracranial aneurysm is estimated to be approximately 1% for aneurysms 7 to 10 mm in diameter. This risk of rupture increases with aneurysm size and it likewise diminishes as the size of the lesion decreases. This general rule serves as a reasonable interpretation of the results reported in the current body of literature.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic / methods
  • Clinical Trials as Topic / statistics & numerical data
  • Humans
  • Intracranial Aneurysm / diagnosis*
  • Intracranial Aneurysm / epidemiology
  • Intracranial Aneurysm / therapy*
  • Risk Factors