Large clinical trials in musculoskeletal trauma: are they possible? Lessons learned from the international study of the use of rhBMP-2 in open tibial fractures

MeSH terms

• Bone Morphogenetic Protein 2
• Bone Morphogenetic Proteins / therapeutic use*
• Clinical Trials Data Monitoring Committees
• Fractures, Open / therapy*
• Humans
• International Cooperation
• Multicenter Studies as Topic
• Musculoskeletal System / injuries*
• Outcome Assessment, Health Care
• Patient Selection
• Pilot Projects
• Randomized Controlled Trials as Topic*
• Research Design
• Tibial Fractures / therapy*
• Transforming Growth Factor beta / therapeutic use*