Abstract
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adoptive Transfer
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Amino Acid Sequence
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Animals
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Antigen Presentation / genetics
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Antigens, Viral / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / pathology
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CD4-Positive T-Lymphocytes / virology
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Cytotoxicity, Immunologic* / genetics
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Epitopes, T-Lymphocyte / immunology
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Epitopes, T-Lymphocyte / metabolism
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Fas Ligand Protein
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Glycoproteins / immunology
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Histocompatibility Antigens Class II / immunology*
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Influenza A virus / immunology
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Lymphocyte Depletion
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Lymphocytic Choriomeningitis / genetics
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Lymphocytic Choriomeningitis / immunology
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Lymphocytic choriomeningitis virus / immunology*
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Membrane Glycoproteins / physiology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Molecular Sequence Data
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Receptors, Antigen, T-Cell, alpha-beta / deficiency
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Spleen / cytology
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Spleen / immunology
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Spleen / transplantation
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Viral Proteins / immunology
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fas Receptor / physiology
Substances
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Antigens, Viral
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Epitopes, T-Lymphocyte
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Fas Ligand Protein
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Fasl protein, mouse
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Glycoproteins
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Histocompatibility Antigens Class II
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Membrane Glycoproteins
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Receptors, Antigen, T-Cell, alpha-beta
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Viral Proteins
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fas Receptor
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glycoprotein peptide, Lymphocytic choriomeningitis virus