Abstract
A multiresistant Klebsiella pneumoniae isolate was taken from the blood of a 75-year-old patient with nosocomial pneumonia who developed septic shock and failed therapy with imipenem. The isolate presented an MIC of imipenem of 128 microg/ml, and the production of a metallo-beta-lactamase was confirmed by phenotypic and genotypic techniques. We here report, for the first time, the detection of a metalloenzyme (IMP-1)-producing K. pneumoniae clinical strain in Latin America. The gene responsible for this phenotype was found to be bla(IMP-1), carried in a class 1 integron.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anti-Bacterial Agents / pharmacology
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Brazil / epidemiology
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Drug Resistance, Multiple, Bacterial*
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Fatal Outcome
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Humans
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Imipenem / pharmacology
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Klebsiella Infections / epidemiology
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification*
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Male
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Microbial Sensitivity Tests
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Imipenem
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beta-lactamase IMP-1
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beta-Lactamases