Abstract
An association study was performed in 197 migraineurs with regard to a functional serotonin (5-HT) transporter (5-HTT) gene promoter polymorphism that leads to low or high 5-HT uptake activity. The frequency of the less active short allele was increased in migraineurs with aura but not in migraineurs without aura in comparison with the control population (p < 0.001). This indicates that the 5-HTT may be involved in the polygenic etiology of migraine with aura.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Female
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Genotype
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Humans
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Male
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins / genetics*
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Middle Aged
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Migraine with Aura / genetics*
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Nerve Tissue Proteins / genetics*
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Polymorphism, Genetic / genetics*
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Serotonin Plasma Membrane Transport Proteins
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Surveys and Questionnaires
Substances
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins