Abstract
Histiocytic necrotizing lymphadenitis, called Kikuchi-Fujimoto's disease (KFD), is an idiopathic, self-limited condition rarely associated with systemic lupus erythematosus (SLE). The cause of concomitant KFD and SLE is still unknown. We describe a 19-year-old man simultaneously diagnosed with both KFD and SLE complicated with deep vein thrombosis (DVT). To the best of our knowledge, this is the first case report of KFD associated with SLE complicated with antiphospholipid antibody syndrome (APS). Our patient was successfully treated with intravenous pulse methylprednisolone, anticoagulation with heparin, oral hydroxychloroquine, azathioprine, and low-dose aspirin.
MeSH terms
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Administration, Oral
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Adult
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Anti-Inflammatory Agents / therapeutic use
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Anticoagulants / therapeutic use
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Antiphospholipid Syndrome / complications*
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Antiphospholipid Syndrome / drug therapy
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Antiphospholipid Syndrome / pathology
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Antirheumatic Agents / therapeutic use
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Aspirin / therapeutic use
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Azathioprine / therapeutic use
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Heparin / therapeutic use
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Histiocytic Necrotizing Lymphadenitis / complications*
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Histiocytic Necrotizing Lymphadenitis / drug therapy
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Histiocytic Necrotizing Lymphadenitis / pathology
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Humans
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Hydroxychloroquine / therapeutic use
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Injections, Intravenous
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Lupus Erythematosus, Systemic / complications*
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Lupus Erythematosus, Systemic / drug therapy
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Lupus Erythematosus, Systemic / pathology
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Male
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Methylprednisolone / therapeutic use
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Treatment Outcome
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Venous Thrombosis / drug therapy
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Venous Thrombosis / etiology
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Venous Thrombosis / pathology
Substances
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Anti-Inflammatory Agents
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Anticoagulants
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Antirheumatic Agents
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Hydroxychloroquine
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Heparin
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Azathioprine
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Aspirin
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Methylprednisolone