Abstract
We have recently reported that 2',3'dideoxy analogues of our exquisitely potent anti-VZV furanopyrimidine deoxynucleosides are shifted to selective anti-HCMV agents. We now find that the fully deoxygenated 2',3',5'-trideoxy analogue is fully antivirally active. This is taken as proof that these agents act by a novel non-nucleoside mechanism of action.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Cell Line
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Cytomegalovirus / drug effects*
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Dideoxynucleosides / chemistry
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Dideoxynucleosides / pharmacology*
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Furans / chemistry*
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Humans
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Pyrimidine Nucleosides / chemical synthesis*
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Pyrimidine Nucleosides / pharmacology
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Structure-Activity Relationship
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Dideoxynucleosides
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Furans
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Pyrimidine Nucleosides