Changes in induced sputum in the presence of bronchiolitis obliterans syndrome and correlation with spirometry in single and bilateral lung transplant recipients

David J Allen; James E Fildes; Nizar Yonan; Colm T Leonard

doi:10.1016/j.healun.2003.10.003

Changes in induced sputum in the presence of bronchiolitis obliterans syndrome and correlation with spirometry in single and bilateral lung transplant recipients

J Heart Lung Transplant. 2005 Jan;24(1):88-91. doi: 10.1016/j.healun.2003.10.003.

Authors

David J Allen¹, James E Fildes, Nizar Yonan, Colm T Leonard

Affiliation

¹ North West Lung Research Centre, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, UK M23 9LT.

PMID: 15653385
DOI: 10.1016/j.healun.2003.10.003

Abstract

Bronchiolitis obliterans syndrome is a clinical diagnosis based on lung function parameters. Using induced sputum, taken from lung transplant recipients, this paper reports on the correlation between the neutrophil count and the percentage change from postoperative baseline for FEV(1), FEF(50), and FEF(25-75). In double lung transplant recipients the correlations were significant for FEV(1) (r = -0.68, p = 0.002), FEF(50) (r = -0.65, p = 0.016), and FEF(25-75) (r = -0.56, p = 0.016). In single lung transplant recipients, no significant correlations were seen.

MeSH terms

Bronchiolitis Obliterans / metabolism*
Bronchiolitis Obliterans / physiopathology
Bronchiolitis Obliterans / surgery*
Forced Expiratory Flow Rates / physiology
Forced Expiratory Volume / physiology
Humans
Leukocyte Count
Lung Transplantation*
Neutrophils / metabolism
Postoperative Complications / etiology
Postoperative Complications / metabolism
Postoperative Complications / physiopathology
Respiratory Function Tests
Severity of Illness Index
Spirometry
Sputum / chemistry*
Sputum / metabolism
Syndrome
Treatment Outcome
Vital Capacity / physiology