Abstract
The intestinal glucagon-like peptides, GLP-1 and GLP-2, are important regulators of nutrient intake, digestion, absorption and metabolism. Extensive studies have shown that the co-secretion of GLP-1 and GLP-2 is regulated by a variety of dietary nutrient, neural and endocrine inputs. Furthermore, secretion of these peptides is altered in a number of pathological conditions, including type 2 diabetes and obesity. The purpose of this review is to discuss the regulation of GLP-1 and GLP-2 secretion in both health and disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Dietary Carbohydrates / administration & dosage*
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Dietary Fats / administration & dosage*
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Dietary Proteins / administration & dosage
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Eating / physiology*
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Glucagon / metabolism*
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Glucagon-Like Peptide 1
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Glucagon-Like Peptide 2
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Humans
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Neurosecretory Systems / physiology*
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Obesity / metabolism
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Peptide Fragments / metabolism*
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Peptides / metabolism*
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Protein Precursors / metabolism*
Substances
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Dietary Carbohydrates
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Dietary Fats
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Dietary Proteins
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Glucagon-Like Peptide 2
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Peptide Fragments
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Peptides
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Protein Precursors
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Glucagon-Like Peptide 1
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Glucagon